Clinical and Experimental Pediatrics

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Original Article

Effect of growth hormone on neuronal death in hippocampal slice cultures of neonatal rats exposed to oxygen-glucose deprivation

Kyung Sik Hong, Jihui Kang, Myeung Ju Kim, Jeesuk Yu, Young Pyo Chang

Clin Exp Pediatr. 2009;52(5):588-593. Published online May 15, 2009

Purpose : To investigate whether growth hormone (GH) has a protective effect on neurons in hippocampal slice cultures of neonatal rats exposed to oxygen-glucose deprivation (OGD). Methods : Cultured hippocampal slices of 7-day-old rats were exposed to OGD for 60 min. Then, the slices were immediately treated with three doses of GH (5, 50, or 500 µM) in media. The...

Fas/FasL expression in the hippocampus of neonatal rat brains follwing hypoxic-ischemic injury

Young Pyo Chang, Myeung Ju Kim, Young Il Lee, Ik Je Im, Jae Ju Cho, Jong-Wan Kim, Sung Moon Yeo

Clin Exp Pediatr. 2006;49(2):198-202. Published online February 15, 2006

Purpose : Fas is a cell surface receptor that transduces apoptotic death signals. Interaction of extracelluar domain of Fas with Fas ligand(FasL) triggers the apoptotic process in many diseases. We investigated the expression of Fas and FasL in the hippocampus of 7-day-old newborn rat brains following hypoxia-ischemia injury. Methods : The 7-days-old newborn rats were exposed to 8 percent oxygen...

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